Open AccessEpigenetic regulation in cardiac fibrosis
Author(s) -
Liming Yu,
Yong Xu
Publication year - 2015
Publication title -
world journal of cardiology
Language(s) - Uncategorized
Resource type - Journals
ISSN - 1949-8462
DOI - 10.4330/wjc.v7.i11.784
Subject(s) - epigenetics , cardiac fibrosis , medicine , histone , heart failure , fibrosis , extracellular matrix , bioinformatics , dna methylation , cardiac function curve , microbiology and biotechnology , genetics , gene , biology , pathology , gene expression
Cardiac fibrosis represents an adoptive response in the heart exposed to various stress cues. While resolution of the fibrogenic response heralds normalization of heart function, persistent fibrogenesis is usually associated with progressive loss of heart function and eventually heart failure. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. In this mini-review, we summarize recent advances regarding the epigenetic regulation of cardiac fibrosis focusing on the role of histone and DNA modifications and non-coding RNAs.