Open AccessAlterations in cell adhesion proteins and cardiomyopathy
Author(s) -
Jifen Li
Publication year - 2014
Publication title -
world journal of cardiology
Language(s) - English
Resource type - Journals
ISSN - 1949-8462
DOI - 10.4330/wjc.v6.i5.304
Subject(s) - cell adhesion , adhesion , medicine , microbiology and biotechnology , cell , phenotype , pathogenesis , cell adhesion molecule , intracellular , cardiomyopathy , mechanism (biology) , disease , computational biology , bioinformatics , biology , pathology , genetics , heart failure , gene , chemistry , philosophy , organic chemistry , epistemology
Cell adhesive junction is specialized intercellular structure composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clinical and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cellular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.