Open AccessBlood cellular mutant LXR-α protein stability governs initiation of coronary heart disease
Author(s) -
Mansi Arora,
Deepak Kaul,
Yash Paul Sharma
Publication year - 2013
Publication title -
world journal of cardiology
Language(s) - English
Resource type - Journals
ISSN - 1949-8462
DOI - 10.4330/wjc.v5.i8.305
Subject(s) - liver x receptor , peripheral blood mononuclear cell , medicine , mutant , ubiquitin ligase , ubiquitin , coronary occlusion , endocrinology , microbiology and biotechnology , cancer research , biology , gene , nuclear receptor , myocardial infarction , in vitro , biochemistry , transcription factor
To investigate the role of [breast and ovarian cancer susceptibility 1 (BRCA1)-associated RING domain 1 (BARD1)]/BRCA1 E3-ubiquitin ligase complex in governing the stability of mutant liver X receptor-α (LXR-α) protein in coronary heart disease (CHD) subjects.