Open AccessInsulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?
Author(s) -
Emine Kaçar,
Alev Özer,
Salih Serin,
Yakup Gümüşalan,
Fatma İnanç,
Mine Kanat Pektaş
Publication year - 2016
Publication title -
the annals of clinical and analytical medicine
Language(s) - English
Resource type - Journals
ISSN - 2667-663X
DOI - 10.4328/jcam.4329
Subject(s) - medicine , affect (linguistics) , anthropometry , insulin like growth factor , insulin , growth factor , pediatrics , intensive care medicine , communication , receptor , sociology
Aim: The present study aims to clarify the role of insulin like growth factor-1 (IGF-1), insulin like growth factor binding protein-3 (IGFBP-3), ghrelin, and insulin in fetal growth. Material and Method: Based on Turkish standards, 14 newborns were defined as small for gestational age (SGA), 33 newborns were described as appropriate for gestational age (AGA), and 13 newborns were identified as large for gestational age (LGA). IGF-1, IGFBP-3, ghrelin, and insulin levels were measured in umbilical cord and maternal serum. Results: The LGA group had significantly higher levels of IGF-1, IGFBP-3, ghrelin, and insulin in umbilical cord and maternal serum than the SGA group. Umbilical cord and maternal serum levels of IGF-1 and IGFBP-3 correlated significantly and positively with body weight, body length, head circumference, and abdominal circumference of the neonates. Discussion: Based on the findings of the present study, it may be postulated that insulin like growth factor system has a role in fetal growth