Open AccessTreatment of Clarithromycin-Induced Rhabdomyolysis with Continuous Renal Replacement Therapy
Author(s) -
Fatih Aygün,
Fatma Deniz Aygün,
Halıt Çam
Publication year - 2015
Publication title -
the annals of clinical and analytical medicine
Language(s) - English
Resource type - Journals
ISSN - 2667-663X
DOI - 10.4328/jcam.3875
Subject(s) - rhabdomyolysis , renal replacement therapy , clarithromycin , medicine , intensive care medicine , helicobacter pylori
Rhabdomyolysis is a rare, life-threatening syndrome characterized by a diffuse and severe muscle injury. Clinical presentation is variable, ranging from asymptomatic disease to acute renal failure. Clarithromycin, a commonly used macrolide antibiotic, can cause rhabdomyolysis by inhibiting CYP450 enzyme system. Rhabdomyolysis related to combination of macrolide and statins has been previously reported in adults. However, it is rare in children, especially with clarithromycin monotherapy. Herein we report our experience with a severe rhabdomyolysis and acute renal failure following clarithromycin administration in a 8-year-old patient