Open AccessRelationship Between HCV RNA and Serum Alanine Aminotransferase and HCV Genotype Distribution
Author(s) -
Dilara Yıldırım,
Mürşit Hasbek,
Sevil Alkan,
Naim Nur
Publication year - 2015
Publication title -
the annals of clinical and analytical medicine
Language(s) - English
Resource type - Journals
ISSN - 2667-663X
DOI - 10.4328/jcam.2369
Subject(s) - alanine aminotransferase , genotype , medicine , virology , alanine , alanine transaminase , distribution (mathematics) , immunology , genetics , gene , biology , amino acid , mathematical analysis , mathematics
Aim: Hepatitis C virus (HCV) infections is an important health problem all over the world because of inveteracy ratio and causing hepatic failure, cirrhosis and hepatocellular carcinoma. Our aim in this study is to research HCV RNA in the patients detected anti-HCV positivity with enzyme immunoassay (ELISA) and to analysis the association of HCV RNA in the serum of patients with alanine aminoransferase (ALT) levels and HCV genotypes. Material and Method: In anti-HCV positive patients came from various departments to our laboratory HCV RNA level and genotyping were researched with quantitive real time polimerase chain reaction (PCR) Montania 483 (Anatolia Geneworks HCV, Turkey) and anti-HCV tests were studied with ELISA (Advia Centaur XP, Germany), ALT results were analysed retrospectively (Olympus AU2700). Results: In 123 of Anti HCV positive 338 serum (%37) were detected HCV RNA positivity. In the patients who have ALT level more than 40 (%77.6), HCV RNA is positive. Relationship between HCVRNA positive patients and the patients who have ALT level more than 40 is meaningful. (