The Evaluation of the Relationship Between Parvovirus B19 and Hashimato Thyroiditis

Aim: Hashimato thyroiditis also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis is characterized by lymphocyte and plasma cell infiltration of thyroid follicles causing destruction and atrophy in thyroid tissue. Reports on coexistence of several HLA antigen types in Hashimoto thyroiditis may indicate genetic predisposition. Parvovirus B19 is a prevalent and single stranded DNA virus that can cause disease in humans. Parvovirus B 19 infection may be responsible for autoimmune disorders or trigger them. The aim of our study was to evaluate the relationship between Parvovirus B19 and Hashimato thyroiditis. Material and Method: Fifity patients with Hashimato thyroiditis that were admitted to our Internal Medicine outpatient clinic and thirty healthy subjects were included in this study. Parvovirus B19 IgM and IgG were studied by EIA (Virion/Serion, Germany). Statistical analysis of the data was studied with chi-square test at Izmir University School of Medicine Department of Biostatistics . p< 0.05 was accepted as statistically significant. Results: Among 50 patients with Hashimato thyroiditis; three (6%) were Parvovirus B19 IgM positive and 36(72%) were IgG positive. Four (13.3%) patients were IgM positive and 15 (50%) were IgG positive in control group. Statistically there was no significant difference of IgM values between patient and control groups (p>0.05). IgG levels in patient group was statistically significant (