Open AccessInfecÇão crônica por Toxoplasma gondii induzindo hipertrofia de neurônios do plexo mientérico do cólon descendente de Rattus norvegicus
Author(s) -
Janaína Soares,
Neide Martins Moreira,
Aristeu Vieira da Silva,
Débora de Mello Gonçales Sant’Ana,
Eduardo José de Almeida Araújo
Publication year - 2009
Publication title -
revista brasileira de parasitologia veterinária/brazilian journal of veterinary parasitology
Language(s) - English
Resource type - Journals
eISSN - 1984-2961
pISSN - 0103-846X
DOI - 10.4322/rbpv.01802013
Subject(s) - toxoplasma gondii , giemsa stain , biology , myenteric plexus , population , toxoplasmosis , andrology , pathology , anatomy , immunohistochemistry , medicine , immunology , environmental health , antibody , genetics
The effects of the chronic infection due to Toxoplasma gondii tachyzoites on the myenteric neurons of the adult rat descending colon were assessed in this study. Ten male, 60-day-old, Wistar rats, divided into control and experimental group were orally inoculated with 105 tachyzoites from Toxoplasma gondii genotype I strain. After 30 days, the animals were anesthetized and submitted to laparotomy. The descending colon was removed, dissected, and the whole-mounts were staining by Giemsa, in order to observe neurons of the myenteric plexus, followed by quantitative and morphometric analysis. It was verified that the infection caused alterations neither with respect to the dimensions of the organ nor the neuronal population; however, there was a significant increase of the perikarion area and the cytoplasm.