Open AccessIL-10 and TGF-β1 gene polymorphisms in Greek patients with recurrent aphthous stomatitis
Author(s) -
V Kounoupis,
D Andreadis,
M Georgaki,
E Albanidou-Farmaki,
M. Daniilidis,
Anastasios K. Markopoulos,
N Karyotis,
N-G Nikitakis,
Athanasios Poulopoulos
Publication year - 2022
Publication title -
medicina oral, patología oral y cirugía bucal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 56
eISSN - 1698-6946
pISSN - 1698-4447
DOI - 10.4317/medoral.25352
Subject(s) - recurrent aphthous stomatitis , genotype , genotyping , immunology , pathogenesis , medicine , polymerase chain reaction , genetic predisposition , stomatitis , gene , biology , gastroenterology , genetics
Recurrent aphthous stomatitis (RAS) is one of the most frequent inflammatory disorders of the oral mucosa. Cytokines, which play an important role in RAS pathogenesis, participate directly or indirectly in normal, immunological and inflammatory processes and are secreted from cells belonging to innate and adaptive immunity as a consequence of microbial and antigenic stimuli. Gene polymorphisms in specific cytokines may predispose to RAS development. The aim of this study was the investigation and association of IL-10 and TGF-β1 gene polymorphisms with RAS.