Open AccessPrognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma: A systematic review
Author(s) -
E-F Morais,
H-G Morais,
H-D Martins,
L-M Carlan,
A-D Costa,
R-D Freitas
Publication year - 2022
Publication title -
medicina oral, patología oral y cirugía bucal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 56
eISSN - 1698-6946
pISSN - 1698-4447
DOI - 10.4317/medoral.24922
Subject(s) - medicine , grading (engineering) , stroma , cochrane library , pathology , head and neck squamous cell carcinoma , h&e stain , oncology , meta analysis , head and neck , head and neck cancer , cancer , immunohistochemistry , surgery , biology , ecology
Analysis of the tumor microenvironment has been proposed as a strategy for the treatment and prognosis of different neoplastic processes. A grading system based on the tumor-stroma ratio (TSR), which evaluates the proportion of stroma in relation to neoplastic parenchyma at the invasion front, has shown a strong prognostic value in different neoplastic processes. The aim of the present systematic review was to understand the role of the TSR in head and neck squamous cell carcinoma (HNSCC), evaluating its correlation with clinical and prognostic parameters.