Open AccessPeriodontitis and alzheimer´s disease
Author(s) -
Daniel Sansores-España,
Arelly Carrillo-Ávila,
Samanta MelgarRodríguez,
Jaime DíazZúñiga,
Víctor Manuel Martínez-Aguilar
Publication year - 2021
Publication title -
medicina oral, patología oral y cirugía bucal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 56
eISSN - 1698-6946
pISSN - 1698-4447
DOI - 10.4317/medoral.23940
Subject(s) - proinflammatory cytokine , neuroinflammation , neurodegeneration , periodontitis , inflammation , microglia , medicine , dementia , neuroscience , disease , immunology , systemic inflammation , pathology , biology
Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation.