Open AccessInvestigation of PTEN promoter methylation in ameloblastoma
Author(s) -
Puangwan Lapthanasupkul,
Boworn Klongnoi,
Apiwat Mutirangura,
Nakarin Kitkumthorn
Publication year - 2020
Publication title -
medicina oral, patología oral y cirugía bucal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 56
eISSN - 1698-6946
pISSN - 1698-4447
DOI - 10.4317/medoral.23498
Subject(s) - pten , tensin , cancer research , methylation , ameloblastoma , biology , carcinogenesis , microbiology and biotechnology , gene , pi3k/akt/mtor pathway , genetics , signal transduction , maxilla , anatomy
Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene. Inactivation of PTEN has been reported in various types of cancers. PTEN promoter methylation possibly underlies PTEN inactivation, which results in tumorigenesis. The aim of this study was to investigate whether PTEN promoter methylation contributes to PTEN inactivation in ameloblastoma and its associated protein expression.