Open AccessTomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis
Author(s) -
Guilherme Simpione,
Rogério Jardim Caldas,
Mariana Quirino Silveira Soares,
Izabel Régina Fischer Rubira-Bullen,
Paulo S. Santos
Publication year - 2020
Publication title -
journal of clinical and experimental dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.481
H-Index - 23
ISSN - 1989-5488
DOI - 10.4317/jced.56265
Subject(s) - medicine , osteonecrosis of the jaw , bisphosphonate , bisphosphonate associated osteonecrosis of the jaw , dentistry , osteoporosis , mandible (arthropod mouthpart) , zoledronic acid , radiology , botany , biology , genus
Bisphosphonates (BP) are synthetic pyrophosphate-like substances with antiresorptive properties and specifically affect osteoclastic activity. In 2007, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined diagnostic criteria for Osteonecrosis of the Jaws Associated with Bisphosponates (BRONJ). BRONJ is mainly diagnosed by clinical features, but the detection of early bone changes by imaging may help prevent and better understand the disease. The objective of this study was to evaluate maxillary changes in CBCT in patients using BP.