Open AccessAnti-hypoxia effects of ginseng (Panax Ginseng C A Meyer) oligopeptides in mice
Author(s) -
Di Li,
Jun Ren,
JingQing Sun,
Lan Wu,
Peng Liu,
Yong Li
Publication year - 2022
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v20i7.18
Subject(s) - ginseng , hypoxia (environmental) , lactate dehydrogenase , chemistry , vascular endothelial growth factor , pharmacology , endocrinology , medicine , biochemistry , oxygen , enzyme , vegf receptors , alternative medicine , organic chemistry , pathology
Purpose: To study the anti-hypoxia effects of ginseng oligopeptides (GOPs) in mice.
Methods: Mice were randomly assigned to six groups: vehicle control group, whey protein-fed group (0.30 g/kg body weight, BW), and four groups given GOP at doses of 0.075, 0.150, 0.300, 0.600 g/kg BW. All treatments were administered via gavage once a day for a total of 30 days.
Results: GOPs significantly extended survival times under normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia. Moreover, GOPs enhanced the levels of RBC, Hb and Hct; decreased brain malonaldehyde (MDA) and lactate contents, enhanced brain lactate dehydrogenase (LDH) activity, and upregulated the mRNA expression levels of hypoxia-inducible factor 1alpha (HIF1α) and vascular endothelial growth factor (VEGF).
Conclusion: GOPs exert anti-hypoxia effects via mechanisms which may involve improvement of oxygen-carrying capacity of blood and oxygen utilization, reduction of lipid peroxidation-associated lesions, enhancement of brain capacity to buffer against lactic acidosis, promotion of angiogenesis, and regulation of response to hypoxia.