Open AccessSensitive and rapid spectrophotometric methods for sertraline monitoring in pharmaceutical formulations
Author(s) -
Ali Sayqal,
Amr L. Saber
Publication year - 2022
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v20i6.20
Subject(s) - bromophenol blue , chemistry , chromatography , reagent , methyl orange , detection limit , combinatorial chemistry , nuclear chemistry , organic chemistry , photocatalysis , catalysis
Purpose: To develop simple, rapid, and selective spectrophotometric methods for the assay of sertraline in a pharmaceutical formulation.
Method: These methods depend on the formation of colored ion-pair complexes between the drug and five different reagents; methyl blue (MB), bromophenol red (BPR), methyl green (MG), phenol red (PR), and methyl orange (MO) in B-R buffer solutions of pH ranging from 2.0 – 8.0. The colored products were measured at 668, 747, 647, 717, and 553 nm, respectively.
Results: The calibration graphs were linear over the concentration range of 2 – 18 μg/mL for MB and BPR, and 2 – 16 μg/mL for MG, PR, and MO. In all cases, the reaction stoichiometry was 1:1. The proposed methods were successfully applied to solid-dose pharmaceutical preparations (tablets). Excipients in the commercial formulation did not interfere with the analysis.
Conclusion: The investigated methods can be recommended for routine analysis and quality control where cost-effectiveness, high specificity of the analytical technique, and time are of great importance.