Open AccessAntidiabetic effects of ethanol extract of Uromastyx hardwickii Smith (Agamidae) skin on streptozotocin-induced diabetes mellitus in mice
Author(s) -
Waqas Ahmad Shams,
Samuel O. Onoja,
Gauher Rehman,
Saif Ul Islam,
K. Khan,
M Ibrar,
Saima B. Sia,
Saba G. Ayaz,
Sajid Ali,
Muhammad Israr,
Aziz Ullah,
Dawood Safi
Publication year - 2022
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v20i3.27
Subject(s) - streptozotocin , diabetes mellitus , creatinine , medicine , hemoglobin , urea , endocrinology , ethanol , chemistry , biochemistry
Purpose: To investigate the in vivo hypoglycemic potential of the ethanol extract of Uromastyx hardwickii skin (EEUHS).
Methods: Streptozotocin-induced diabetic mice received graded doses (100 and 200 mg/kg) of EEUHS for oral glucose tolerance and hypoglycemic test. The effects of EEUHS on body weight gain, urea, creatinine, cholesterol and hemoglobin concentration were also investigated.
Result: The blood glucose concentrations of the EEUHS-treated groups were diminished (p < 0.05) relative to the diabetic control group. The urea, creatinine and cholesterol levels of the EEUHS-treated groups were lower (p < 0.05), but their hemoglobin concentrations were higher (p < 0.05) relative to the diabetic control group.
Conclusion: The EEUHS elicits hypoglycemic effects and ameliorates complications of diabetes mellitus in streptozotocin-induced diabetic mice. This suggests that EEUHS can potentially be developed for the management of diabetic patients.