Open AccessEnhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method
Author(s) -
Nayyer Islam,
Muhammad Irfan,
Nasir Abbas,
Haroon Khalid Syed,
Muhammad Shahid Iqbal,
Ikram Ullah Khan,
Akhtar Rasul,
Sana Inam,
Amjad Hussain,
Noor ul Amin Mohsin,
Mohammad Sohail Arshad,
Mohsin Ali
Publication year - 2020
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v19i9.1
Subject(s) - solubility , dissolution , differential scanning calorimetry , dispersion (optics) , poloxamer , friability , distilled water , materials science , fourier transform infrared spectroscopy , chromatography , chemistry , aqueous solution , nuclear chemistry , chemical engineering , organic chemistry , composite material , thermodynamics , ethyl cellulose , optics , copolymer , engineering , polymer , physics
Purpose: To investigate the efficiency of different solubilizing agents in improving solubility as well as dissolution rate of ebastine (a BCS class II drug) by incorporating prepared solid dispersion into fast disintegrating tablets.Method: The solubility of ebastine was determined in distilled water, lipids and solubilizing agents. Subsequently, the binary solid dispersions were prepared by kneading method using varying weight ratios of ebastine and solubilizing agents. The solid dispersions were then incorporated into fast disintegrating tablets (SD-FDT). Central composite rotatable design (CCD) was used to determine the impact of super disintegrating agents on disintegration time and friability of tablets. The solubility and dissolution rate of developed SD-FDT were compared with a marketed brand. The solid dispersion particles were characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder x-ray diffraction (P-XRD) and scanning electron microscopy (SEM).Results: The saturated solubility of pure ebastine in water was 0.002 ± 0.041 mg/ml while the aqueous solubility of EBT/poloxamer solid dispersion SET3 (P) was 0.018 ± 2.510 mg/ml; on the other hand, EBT/soluplus solid dispersion SET1(S) has an aqueous solubility of 0.242 ± 1.390 mg/ml. Within 30 min, drug release was 14.00 ± 1.77, 78.00 ± 2.31 and 98.70 ± 2.54 % from pure EBT, SET3 (P) and SET1(S), respectively.Conclusion: The solubility and dissolution rate of ebastine has been successfully enhanced by incorporating its solid dispersion in fast-disintegrating tablets (SD-FDT).
Keywords: Ebastine, Solid dispersion, Poloxamer 188, Soluplus, Solubility, Dissolution