Open AccessArecoline induces dual modulation of blood pressure in rat, including an initial downregulation and a subsequent upregulation
Author(s) -
Jiashan Wu,
Lijuan Chen,
Meiping Deng,
Xiaowen Ye,
Jiang Xiao-xia,
Jiangliu Fu,
Peiling Zhou,
Changzheng Zhang
Publication year - 2020
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v19i8.11
Subject(s) - downregulation and upregulation , arecoline , chemistry , blood pressure , endocrinology , medicine , biochemistry , receptor , muscarinic acetylcholine receptor , gene
Purpose: To determine the role of arecoline in cardiovascular modulation in rats.Methods: After rats were anaesthetized with intraperitoneal urethane (1.4 g/kg body weight), saline or arecoline (at doses of 1.0, 3.0 and 10.0 mg/kg) was intraperitoneally administered, and blood pressure (BP) was continuously recorded using a physiological apparatus. Mean arterial pressure (MAP), maximum changes in MAP and reaction time due to arecoline stimulations were calculated and analyzed.Results: Arecoline induced biphasic modulation in BP, including an initial downregulation followed by a subsequent upregulation. The MAP and maximum change in MAP exhibited a concentration-dependent effect in the downregulation phase (p 0.05 within each group), while BP reaction time showed a dose-dependent prolongation in both downregulation and upregulation phases (ps < 0.01 within each group). Remarkably, arecoline-induced BP downregulation more rapidly and drastically than upregulation in each arecoline group.Conclusion: These results indicate that arecoline exerts a complex effect in cardiovascular modulation that should be considered as side effects in the clinical use of arecoline and/or with the habitual chewing of areca nuts.
Keywords: Arecoline, Blood pressure, Downregulation, Upregulation