Open AccessCurrent application of metabolomics in the elucidation of processing mechanisms used in Chinese materia medica: A review
Author(s) -
Ting Huang,
Yunbin Jiang,
Yanfei Zhang,
Yu-Tian Lei,
Guihua Jiang
Publication year - 2020
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v19i6.29
Subject(s) - materia medica , metabolomics , mechanism (biology) , traditional chinese medicine , computer science , biochemical engineering , medicine , bioinformatics , biology , engineering , alternative medicine , philosophy , epistemology , pathology
Processing, a key characteristic of traditional Chinese medicine (TCM), enhances the efficacy and safety of Chinese materia medica (CMM) in clinics. It plays an important role in TCM. Studies on processing mechanisms involved in CMM promote the development of TCM. However, most studies on the mechanisms used for processing CMM do not reflect the holistic theory of TCM because they are based only on analysis of some specific chemical components and biochemical indices which do not support the TCM characteristics of network target and multicomponent therapeutics. Fortunately, the perspective of systems biology is consistent with the holistic theory of TCM. Metabolomics, a key tool in systems biology, has been widely used to investigate the processing mechanism of CMM for many years. In this work, current applications of metabolomics in elucidating mechanisms used for processing of CMM were systematically reviewed and discussed in terms of changes in chemical components, toxicity and efficacy of CMM before and after processing. This work provides researchers a clear and concise reference on the current application of metabolomics in investigation of mechanisms used in processing of CMM. Moreover, this work provides a guide on how to investigate the mechanisms used in processing of CMM, based on metabolomics.
Keywords: Chinese materia medica, Processing mechanism, Metabolomics, Holistic theory