Open AccessTargeting of protein expression in renal disease using siRNA – A review
Author(s) -
Manal Buabeid,
Nihal Abdalla Ibrahim,
Zelal Kharaba,
Muhammad Ihtisham Umar,
Ghulam Murtaza
Publication year - 2020
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v19i6.28
Subject(s) - disease , small interfering rna , identification (biology) , computational biology , kidney , rna , bioinformatics , biology , medicine , pathology , gene , genetics , botany
The kidneys have rarely been used as a target in the systemic delivery of siRNA when compared to other tissues or organs in the body. This review article deals with various modalities adopted to deliver siRNA to the renal system under different normal and pathophysiological states. In this article, the authors have reviewed extensive clinical data that describe the use of siRNA for the treatment of renal diseases. Conventional and 3D modeling utilizes the existing genome-based RNA libraries, which facilitated the identification of molecular pathways involved in renal diseases.
Keywords: siRNA, kidney disease, targeting proteins, signal pathways