Open AccessErratum for “Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats”
Author(s) -
Sarawoot Palipoch,
Phanit Koomhin,
Chuchard Punsawad,
Prasit Suwannalert
Publication year - 2021
Publication title -
tropical journal of pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.209
H-Index - 36
eISSN - 1596-5996
pISSN - 1596-9827
DOI - 10.4314/tjpr.v18i5.33
Subject(s) - cyp2e1 , malondialdehyde , proinflammatory cytokine , chemistry , nicotinamide adenine dinucleotide phosphate , ethanol , liver injury , oxidative stress , saline , pharmacology , antioxidant , biochemistry , traditional medicine , inflammation , oxidase test , endocrinology , medicine , cytochrome p450 , enzyme
Purpose: To investigate the antioxidant and anti-inflammatory effects of aqueous leaf extract of T. laurifolia against alcoholic liver injury in rats.
Methods: Male Wistar rats were administered either normal saline, ethanol (EtOH), normal saline with low or high dose T. laurifolia leaf extract (TL-LD or TL-HD), EtOH with TL-LD or EtOH with TL-HD. Blood biochemical indices: hepatic malondialdehyde (MDA) levels, liver histopathology, hepatic cytochrome P450 2E1 (CYP2E1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and proinflammatory cytokines, including interleukin 1 beta (IL-1β) and tumor necrotic factor alpha (TNF-α) mRNA expressions, were determined using standard methods.
Results: The leaf extract of T. Laurifolia decreased hepatic MDA levels, improved liver pathology and down-regulated mRNA expressions of CYP2E1, NADPH oxidase and pro-inflammatory cytokinesin ethanol-treated rats.
Conclusion: These results demonstrate that aqueous extract of T. Laurifolia exerts hepatoprotective effect against alcoholic liver injury through a mechanism involving inhibition of oxidative stress and inflammation.