Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin | Zendy

C Chen | Zendy; Xu Xu | Zendy; Yinghui Li | Zendy; Haile Ma | Zendy

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Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin

Author(s) -

C Chen,

Xu Xu,

Yinghui Li,

Haile Ma

Publication year - 2015

Publication title -

tropical journal of pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.209

H-Index - 36

eISSN - 1596-5996

pISSN - 1596-9827

DOI - 10.4314/tjpr.v14i9.4

Subject(s) - paeonol , solubility , chemistry , differential scanning calorimetry , cyclodextrin , aqueous solution , nuclear chemistry , thermogravimetric analysis , thermal stability , stoichiometry , infrared spectroscopy , chromatography , organic chemistry , medicine , physics , alternative medicine , pathology , thermodynamics

Purpose: To improve the solubility of paeonol in water by complexing with hydroxypropyl-β-cyclodextrin (HP-β-CD) and also to characterize the physicochemical properties of the complex.Methods: The complex of paeonol and HP-β-CD was prepared by freeze-drying method. Its physicochemical properties were studied by phase-solubility method, ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), scanning electron microscopy (SEM), x-ray diffractometry (XRD) and thermogravimetric/differential scanning calorimetry (TG/DSC).Results: The phase-solubility results showed that paeonol formed a 1:1 stoichiometric complex with HP-β-CD while UV and IR spectra suggested that HP-β-CD and paeonol in the complex interacted by a non-covalent bond. SEM and XRD indicate that the heat stability of paeonol was significantly improved by complexing with HP-β-CD.Conclusion: Paeonol can be efficiently complexed with HP-β-CD to form a complex by freeze-drying method. The aqueous solubility and heat stability of paeonol is significantly improved by complexation HP-β-CD.Keywords: Paeonol, Hydroxypropyl-β-cyclodextrin, Complexation, Aqueous solubility, Heat stability

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