Open AccessAntimicrobial susceptibility pattern and multidrug resistance ındex in Pseudomonas aeruginosa among clinical isolates in Denizli, Turkey
Author(s) -
Selma Kırac,
Dilek Keskin,
Muradiye Yarar
Publication year - 2018
Publication title -
tanzania journal of health research/tanzania journal of health research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.201
H-Index - 25
eISSN - 1821-6404
pISSN - 1821-9241
DOI - 10.4314/thrb.v20i3.6
Subject(s) - pseudomonas aeruginosa , colistin , amikacin , netilmicin , antimicrobial , microbiology and biotechnology , multiple drug resistance , gentamicin , antibiotic resistance , biology , antibiotics , tazobactam , drug resistance , medicine , bacteria , imipenem , tobramycin , genetics
Background: Pseudomonas aeruginosa is an important hospital infection agent causing morbidity and mortality with the ability to gain resistance to many antimicrobials. The objective of this study was to determine the sensitivity profiles of nosocomial P.aeruginosa isolates in Denizli, Turkey.Methods: A total 120 P. aeruginosa strains which were isolated from specimens sent to the microbiology laboratory between January 2015 and December 2015 were investigated. Antimicrobial resistance was determined by agar disc diffusion method using Mueller-Hinton agar according to Clinical and Laboratory Standards Institute recommendations.Results: With respect to sensitivity pattern, the most sensitive antimicrobials were Amikacin, colistin, tobramisin, netilmicin and gentamicin and the resistance rates were detected as 97%, 96%, 92%, 90%, 83%, respectively over 120 P. aeruginosa strains. The sensitivity rates for the other antimicrobials were 56% for Piperacilin and 54% for Tazobactam. P. aeruginosa strains 62 (52%) isolates showed multiple antimicrobial resistance to 13 antimicrobialsConclusion: To prevent the spread of the resistant bacteria, it is critically important to have strict antimicrobial policies while surveillance programmes for multidrug resistant organisms and infection control procedures need to be implemented. In the meantime, it is desirable that the antimicrobial susceptibility pattern of bacterial pathogens like P. aeruginosa in specialized clinical units to be continuously monitored and the results readily made available to clinicians so as to minimize the development of resistance.