Open AccessHistiocytosis in Nigerian children: A report of two variants
Author(s) -
E.Y. Udo,
I. Precious Oloyede,
E.U. Bassey,
O. Udoh
Publication year - 2021
Publication title -
nigerian journal of paediatrics
Language(s) - English
Resource type - Journals
ISSN - 0302-4660
DOI - 10.4314/njp.v48i2.8
Subject(s) - medicine , neutrophilia , histiocytosis , sinus histiocytosis with massive lymphadenopathy , histology , cervical lymphadenopathy , cd68 , pathology , biopsy , histiocyte , histiocytosis x , lymph , dermatology , cervical lymph nodes , immunohistochemistry , disease , cancer , metastasis
Histiocytoses are a rare group of proliferative disorders with very similar clinical and histological pictures. We present a case report of two variants seen in an eight-month-old female and five-month-old male in a tertiary hospital in southern Nigeria. They both presented with painless neck swellings and fever, leucocytosis, neutrophilia and lymphopenia. Initial histologic examinations of the cervical lymph nodes biopsy posed a diagnostic conundrum. However, Immuno-histochemical analysis done on both sample showed CD1a, positive S100 in keeping with Langerhans cell histiocytosis in the former. While, that of the latter showed strongly positive CD68, positive S-100 in 30% cells in keeping with Sinus histiocytosis with massive lymphadenopathy (SLMH) in the latter. Clinicians should have a high index of suspicion for histiocytosis in children presenting with generalised lymphadenopathy. Also, apart from the routine histology, immunohistochemistry analysis is recommended for all cases