Open AccessOxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defence systems and the promise of improved outcome
Author(s) -
Patrick O. Eghwrudjakpor,
A.B Allison
Publication year - 2010
Publication title -
nigerian journal of medicine/the nigerian journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2667-0526
pISSN - 1115-2613
DOI - 10.4314/njm.v19i1.52466
Subject(s) - oxidative stress , neuroprotection , reactive oxygen species , traumatic brain injury , antioxidant , medicine , endogeny , pharmacology , bioinformatics , neuroscience , chemistry , biology , biochemistry , psychiatry
Management of brain injury can pose enormous challenges to the health team. There are many studies aimed at discovering or developing pharmacotherapeutic agents targeted at improving outcome of head-injured patients. This paper reviews the role of oxidative stress in neuronal loss following traumatic brain injury and presents experimental and clinical evidence of the role of exogenous antioxidants as neuroprotectants.