Open AccessZidovudine induced pure red cell aplasia: A case report
Author(s) -
Anjum Hassan,
Aliyu Babadoko,
Aisha Indo Mamman,
S A Ahmed
Publication year - 2010
Publication title -
nigerian journal of medicine/the nigerian journal of medicine
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2667-0526
pISSN - 1115-2613
DOI - 10.4314/njm.v18i3.51210
Subject(s) - zidovudine , medicine , pure red cell aplasia , lamivudine , bone marrow aplasia , aplastic anemia , bone marrow , anemia , aplasia , nevirapine , stavudine , nucleoside analogue , immunology , gastroenterology , viral load , human immunodeficiency virus (hiv) , viral disease , antiretroviral therapy , virus , nucleoside , biology , biochemistry , hepatitis b virus
Zidovudine, a Nucleoside Reverse Transcriptase Inhibitor (NRTI) is one of the earliest antiretroviral agents used as a combination in the Highly Active Antiretroviral Therapy (HAART) for the treatment of HIV infection. Its use is however not without adverse effect particularly bone marrow aplasia leading to varying degrees of cytopenias predominantly anaemia. This calls for adequate evaluation and monitoring of patients on this drug. Its major side effect of anaemia limits its use in some patients. We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.