Open AccessBone Marrow Transplantation (BMT) and Gene Replacement Therapy (GRT) In Sickle Cell Anemia
Author(s) -
Misaki Wayengera
Publication year - 2008
Publication title -
nigerian journal of medicine/the nigerian journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2667-0526
pISSN - 1115-2613
DOI - 10.4314/njm.v17i3.37390
Subject(s) - sickle cell anemia , transplantation , medicine , hemoglobinopathy , anemia , bone marrow , genetic disorder , disease , immunology , hemolytic anemia , pathology
Sickle cell anemia (SCA) forms one of the neglected tropical disease of genetic aetiology Unlike many complex genetic diseases inherited on a multiallelic pattern, SCA is a hemoglobinopathy of Mendelian type genetic inheritance. The SCA trait is inherited through a recessive autosomal link, with the homozygotes (SS) manifesting clinical disease, while the heterozygoste (AS) are clinically normal-exept in states of hypoxia or severe infection.