Open AccessBody Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin
Author(s) -
Malami Dikko,
Y. Sarkingobir
Publication year - 2020
Publication title -
journal of applied science and environmental management
Language(s) - English
Resource type - Journals
eISSN - 2659-1499
pISSN - 2659-1502
DOI - 10.4314/jasem.v24i8.5
Subject(s) - tamsulosin , histopathology , body weight , medicine , histopathological examination , urology , significant difference , normal group , lesion , pathology , hyperplasia
The objective of this study was to investigate histopathology of livers and carry out body weight determination in normal rats administered with tamsulosin. Standard methods and procedures were used in this study. The results were revealed. Pertaining weight, at the 3rd , 6th and 8th weeks of the study, no significant difference (P>0.05) in weight was found in the group of rats treated with carvedilol (positive control), tamsulosin low dose (12μg/kg) and high dose tamsulosin (40μg/kg) compared to normal control group, respectively. Other inter-groups comparisons were not significantly different, respectively. Pertaining liver morphology, liver sections of groups revealed no significant histological lesions compared to the normal control group at the 6th and 8th weeks of the study, respectively. This study revealed that the tamsulosin cause no histopathological lesion, thus the drug might be safe to the liver and its biochemical processes.
Keywords: Tamsulosin, Liver, histopathology, weight, Wistar rats