Open AccessEfficiency of Galanti and Guisti Method of ADA Estimation in Comparison with the Gold Standard
Author(s) -
Manasa Reddy Dubba,
V. Ramyashree,
S. S. Harshitha,
Monalisa Biswas,
Revathi P Shenoy,
Varashree Bolar Suryakanth
Publication year - 2020
Publication title -
ethiopian journal of health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.479
H-Index - 20
eISSN - 2413-7170
pISSN - 1029-1857
DOI - 10.4314/ejhs.v30i6.7
Subject(s) - autoanalyzer , hypoxanthine , gold standard (test) , comparability , adenosine deaminase , computer science , inosine , estimation , chromatography , medicine , statistics , mathematics , chemistry , biochemistry , adenosine , enzyme , engineering , systems engineering , combinatorics
Adenosine Deaminase, the key enzyme of purine metabolism catalyzing the irreversible hydrolytic deamination of adenosine to inosine is implicated in a varied spectrum of human diseases ranging from SCID to TB and pneumonia. Estimation of ADA offers an easy, relatively affordable and reliable diagnostic alternative and/ or adjunct (specially in a TB endemic nation) which emphasizes the necessity of a feasible and implementable alternative method to the Diazyme method of ADA estimation requiring high end autoanalyzer and infrastructural setup.