Open AccessFe+3-montmorillonite K10: As an effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and –thiones
Author(s) -
Leila Zare Fekri,
Mohammad Nikpassand,
Mahsa Movaghari
Publication year - 2017
Publication title -
bulletin of the chemical society of ethiopia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.288
H-Index - 25
eISSN - 1726-801X
pISSN - 1011-3924
DOI - 10.4314/bcse.v31i2.12
Subject(s) - chemistry , thiourea , ethyl acetoacetate , biginelli reaction , montmorillonite , urea , catalysis , grind , organic chemistry , reaction conditions , nuclear chemistry , grinding , mechanical engineering , engineering
In this study, a novel, clean, convenient, appropriate and environmentally benign route to dihydropyrimidinone and thione derivatives has been developed using the reaction between various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of Fe+3-montmorillonite K10 under grind condition. The present methodology has several advantages such as simple work-up, solvent-free conditions, environmental friendliness and shorter reaction time along with high yields. Several aromatic aldehydes carrying either electron-releasing or electron-withdrawing substituents in the ortho and para positions were tested in this reaction. Another important feature of this procedure is the survival of a variety of functional groups under the reaction conditions. All of synthesized compounds were characterized by IR, 1HNMR, 13CNMR and elemental analyses