Open AccessAntimicrobial activity and phytochemistry of methanolic stem bark extract of <i>Melia azedarach </i>(Linn.)
Author(s) -
Mansoor Ahmed,
A. Bukar,
M.Y. Amuda,
A. Babagana
Publication year - 2020
Publication title -
bayero journal of pure and applied sciences
Language(s) - English
Resource type - Journals
ISSN - 2006-6996
DOI - 10.4314/bajopas.v12i1.61s
Subject(s) - melia azedarach , antimicrobial , phytochemical , traditional medicine , bark (sound) , meliaceae , phytochemistry , terpenoid , staphylococcus aureus , biology , microbiology and biotechnology , medicine , botany , bacteria , ecology , genetics
The use of traditional medicine is increasing and gaining popularity throughout the developed and developing countries. About 80 % of the people in developing countries rely on traditional medicine for primary health care. The present study was carried out to evaluate the phytochemical constituents and antimicrobial activity of the stem bark of Melia azedarach extracted using methanol as solvent. Phytochemical screening revealed that methanolic stem bark extract contain alkaloid, cardiac glycoside, flavonoids, saponins, steroid, tannin and terpenoid. Antimicrobial efficiency were tested against four human pathogens: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Streptococcus spp. The diameter of zone of inhibition (ZOI) was measured and it was found that the extract showed a maximum zone of inhibition against Gram negative and Gram positive pathogens and the zone of inhibition was found to be concentration dependent. The result obtained in this study may be indication that alcoholic extracts of this plant could be a possible source of obtaining new and effective herbal medicine to treat infections which justify the ethno medicinal uses of Melia azedarach against infectious diseases agents.
Key words: Melia azedarach, antimicrobial, activity, traditional medicine, extract