Open AccessAn overview on significant human genetics modification in the protection against severe Falciparum malaria
Author(s) -
Usman Ahmad
Publication year - 2018
Publication title -
bayero journal of pure and applied sciences
Language(s) - English
Resource type - Journals
ISSN - 2006-6996
DOI - 10.4314/bajopas.v11i1.28
Subject(s) - malaria , plasmodium falciparum , hemoglobin c , hemoglobin , thalassemia , biology , pyruvate kinase deficiency , genetics , immunology , virology , pyruvate kinase , enzyme , biochemistry , glycolysis
This paper was aimed at expatiating the relevance to which falciparum malaria are protected due to various genetically modified factors which include Hemoglobin S, Hemoglobin E, Hemoglobin C, Hemoglobin F, Alpha and beta thalassemia, ovalocytosis, Glucose – 6- Phosphate dehydrogenase deficiency, Human leucocyte antigen (HLA) – BW53, DRBI 1302, DQBI 0501, Pyruvate kinase or PKLR gene. However, human genetics is one of the elements can be used in planning of co- ordinated attack on disease, since it sometime give an avenue to differentiate those groups or individual who are susceptible from those who are not.Keywords: malaria, hemoglobin, genetically modified factors