Open AccessFlavonoids, anti-inflammatory activity and cytotoxicity of <i>Macfadyena unguis-cati</i> l.
Author(s) -
E. A. Aboutabl,
F. A. Hashem,
Amany A. Sleem,
A. A. Maamoon
Publication year - 2008
Publication title -
african journal of traditional complementary and alternative medicines
Language(s) - English
Resource type - Journals
eISSN - 2505-0044
pISSN - 0189-6016
DOI - 10.4314/ajtcam.v5i1.31251
Subject(s) - acacetin , chemistry , apigenin , ethyl acetate , ethanol , quercitrin , lupeol , cytotoxicity , verbascoside , kaempferol , stereochemistry , flavonoid , traditional medicine , biochemistry , medicine , antioxidant , glycoside , in vitro
Ethyl acetate and ethanol extracts of unflowering aerial part of Macfadyena unguis-cati L. (Fam. Bignoniaceae) were found to be rich in phenolic compounds. From ethyl acetate extract, six flavonoids were identified, 8, methoxy, acacetin, 7-O glucoside; 6, methoxy apigenin 7-O glucoside; 4'-O methyl scutellarin, 6-O apiosyl galactoside; acacetin, 7-O glucosyl, 8-C rhamnosyl, 3-O-alpha arabinofuranoside; 4'-methyl, 6- methoxy kaempferol, 7-O, 8-C diglucoside and vicenin II were isolated, while 6, methoxy, acacetin 7-O glucoside; and quercitrin were isolated from ethanol extract. These compounds were characterized and identified by their physicochemical and spectral data. The crude ethanol extract exhibited significant anti-inflammatory activity (80.47%) and moderate cytotoxic activity against lung cell line.