Open AccessAntihyperglycemic Effects Of Separate And Composite Extract Of Root Of <i>Musa paradisiacal</i> And Leaf Of <i>Coccinia indica</i> In Streptozotocin-Induced Diabetic Male Albino Rat.
Author(s) -
Chhanda Mallick,
Kanu Chatterjee,
Mehuli GuhaBiswas,
Debidas Ghosh
Publication year - 2008
Publication title -
african journal of traditional complementary and alternative medicines
Language(s) - English
Resource type - Journals
eISSN - 2505-0044
pISSN - 0189-6016
DOI - 10.4314/ajtcam.v4i3.31230
Subject(s) - streptozotocin , glycogen , insulin , diabetes mellitus , hexokinase , glucose 6 phosphatase , medicine , chemistry , endocrinology , enzyme , biochemistry , metabolism , glycolysis
We evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of Musa paradisiaca and leaf of Coccinia indica in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats. We measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quantification of glycogen in liver and in skeletal muscle and serum insulin level. We noted that after treatment of aqueous methanolic extract of above plant parts in separate as well as in composite manner at a concentration of 80 mg/100 g body weight/day to streptozotocin-induced diabetic rat resulted in a significant remedial effect on blood glucose level as well as carbohydrate metabolic enzymes and the quantity of liver and skeletal muscle glycogen. Serum insulin level that was diminished in streptozotocin-induced diabetic rat recovered significantly after the co-administration of extract of above plant parts. All the above parameters showed a more potent remedial effect after composite extract treatment with respect to separate treatment and none of the extract has any general metabolic toxicity induction.