Open AccessAmlodipine besylate impairs the morphology of bone marrow in adult male wistar rats
Author(s) -
AA Adelaja,
OK Ghazali,
LB Ayantunji,
GO Omotoso
Publication year - 1970
Publication title -
anatomy journal of africa
Language(s) - English
Resource type - Journals
eISSN - 2305-9478
pISSN - 2226-6054
DOI - 10.4314/aja.v6i2.160479
Subject(s) - amlodipine , bone marrow , medicine , calcium channel blocker , saline , adult male , endocrinology , pharmacology , pathology , calcium , blood pressure
Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina. In adult man, the treatment regimen is 5 or 10 mg daily. This study evaluated the effects of prolonged oral administration of Amlodipine Besylate on the morphology of bone marrow in adult male Wistar rats. Sixteen rats (140 - 190 g) comprising of four groups were employed in the study. Rats of Control Group I received physiological saline orally while rats of Experimental Groups II - IV received oral administrations of 5, 10 and 15 mg/kg bodyweight of Amlodipine Besylate respectively for nine weeks. Histo-pathological examinations of the bone marrow showed normal cytoarchitecture of erythrocytes and leukocytes in rats of Control Group I. However, dose-dependent degeneration and lyses of erythrocytes and leukocytes were observed in amlodipine-treated rats. In conclusion, impaired morphology of the bone marrow were observed in amlodipine-treated adult male Wistar ratsKey words: Amlodipine Besylate, bone marrow, morphology, rats.