Molecular characterization of high-risk humanpapillomavirus genotypes in women with or without cervical lesions at VIA/VILI in Kara, Togo | Zendy

Essolakina Dolou Dolou | Zendy; Akouélé P. Kuassi-Kpede | Zendy; Théodora Mahoukèdè Zohoncon | Zendy; Ina Marie Angèle Traore | Zendy; Gnatoulma Katawa | Zendy; Rogomenoma Alice Ouédraogo | Zendy; Esther Mah Alima Traoré | Zendy; Prosper Bado | Zendy; Clarisse T. Ouedraogo | Zendy; Florencia Wendkuuni Djigma | Zendy; AbdoulSamadou Aboubakari | Zendy; Simplice Damintoti Karou | Zendy; Jacques Simporé | Zendy

Open Access

Molecular characterization of high-risk humanpapillomavirus genotypes in women with or without cervical lesions at VIA/VILI in Kara, Togo

Author(s) -

Essolakina Dolou Dolou,

Akouélé P. Kuassi-Kpede,

Théodora Mahoukèdè Zohoncon,

Ina Marie Angèle Traore,

Gnatoulma Katawa,

Rogomenoma Alice Ouédraogo,

Esther Mah Alima Traoré,

Prosper Bado,

Clarisse T. Ouedraogo,

Florencia Wendkuuni Djigma,

AbdoulSamadou Aboubakari,

Simplice Damintoti Karou,

Jacques Simporé

Publication year - 2021

Publication title -

african health sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 44

eISSN - 1729-0503

pISSN - 1680-6905

DOI - 10.4314/ahs.v21i4.27

Subject(s) - genotype , medicine , cervical cancer , logistic regression , hpv infection , human papillomavirus , gynecology , virology , cancer , gene , biology , genetics

Background: Persistent infection with high-risk (HR) papillomavirus (HPV) genotypes plays a central role in the pathogenesis of invasive cervical cancer. Objectives: This study aimed to determine the prevalence and distribution of HR-HPV among women with or without cervical lesions at VIA/VILI in Togo. Methods: Cervical samples were collected from 238 women with or without cervical lesions at VIA / VILI and[c3] DNA [c4]was extracted and analyzed by real-time multiplex PCR. Logistic regression analysis was used to determined risk factors associated with HPV infection. inPietro Annigoni Biomolecular Research Center (CERBA / LABIOGENE) in Burkina Faso. Results: The age of the women ranged from 17 to 61 years old, and most were married (73.5%). The prevalence of HRHPV was 35.71% and this was higher in the age range 35-39 years. The six most common genotypes were HPV 31 (18.7%), HPV 52 (13.82%), HPV 68 (13.01%), HPV 66 (9.76%), HPV 58 (8.13%) and HPV 56 (8.13%). Genotypes HPV 18 (4.07%)and HPV 16 (0.81%) were less frequent.[c5] Married or living with a partner was associated with HPV infection ( OR=2,17, IC [1.20-3.91], p<0,009). Conclusion: This study allowed characterizing for the first time in Togo, HR-HPV genotypes. This will help mappingHR-HPV genotypes circulating in West Africa. Keywords: Human papillomavirus; High-risk; Genotyping; Kara; Togo.

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