Open AccessMolecular characterization of high-risk humanpapillomavirus genotypes in women with or without cervical lesions at VIA/VILI in Kara, Togo
Author(s) -
Essolakina Dolou Dolou,
Akouélé P. Kuassi-Kpede,
Théodora Mahoukèdè Zohoncon,
Issouf Traoré,
Gnatoulma Katawa,
Rogomenoma Alice Ouédraogo,
Esther Mah Alima Traoré,
Prosper Bado,
C.M.R. Ouédraogo,
Florencia Wendkuuni Djigma,
AbdoulSamadou Aboubakari,
Simplice Damintoti Karou,
Jacques Simporé
Publication year - 2021
Publication title -
african health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 44
eISSN - 1729-0503
pISSN - 1680-6905
DOI - 10.4314/ahs.v21i4.27
Subject(s) - genotype , medicine , cervical cancer , logistic regression , hpv infection , human papillomavirus , gynecology , virology , cancer , gene , biology , genetics
Background: Persistent infection with high-risk (HR) papillomavirus (HPV) genotypes plays a central role in the pathogenesis of invasive cervical cancer.
Objectives: This study aimed to determine the prevalence and distribution of HR-HPV among women with or without cervical lesions at VIA/VILI in Togo.
Methods: Cervical samples were collected from 238 women with or without cervical lesions at VIA / VILI and[c3] DNA [c4]was extracted and analyzed by real-time multiplex PCR. Logistic regression analysis was used to determined risk factors associated with HPV infection. inPietro Annigoni Biomolecular Research Center (CERBA / LABIOGENE) in Burkina Faso.
Results: The age of the women ranged from 17 to 61 years old, and most were married (73.5%). The prevalence of HRHPV was 35.71% and this was higher in the age range 35-39 years. The six most common genotypes were HPV 31 (18.7%), HPV 52 (13.82%), HPV 68 (13.01%), HPV 66 (9.76%), HPV 58 (8.13%) and HPV 56 (8.13%). Genotypes HPV 18 (4.07%)and HPV 16 (0.81%) were less frequent.[c5] Married or living with a partner was associated with HPV infection ( OR=2,17, IC [1.20-3.91], p<0,009).
Conclusion: This study allowed characterizing for the first time in Togo, HR-HPV genotypes. This will help mappingHR-HPV genotypes circulating in West Africa.
Keywords: Human papillomavirus; High-risk; Genotyping; Kara; Togo.