Open AccessBRAFV600E hot spot mutation in thyroid carcinomas: first Moroccan experience from a single-institution retrospective study
Author(s) -
Meryem Kaabouch,
Hafsa Chahdi,
Naïma Azouzi,
Mohammed Oukabli,
Issam Rharrassi,
Adil Boudhas,
Hassan Jaddi,
Mouna Ababou,
Nadia Dakka,
Amélie Boichard,
Youssef Bakri,
Corinne Dupuy,
Abderrahmane Al Bouzidi,
Rabii Ameziane El Hassani
Publication year - 2020
Publication title -
african health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 44
eISSN - 1729-0503
pISSN - 1680-6905
DOI - 10.4314/ahs.v20i4.40
Subject(s) - medicine , thyroid , incidence (geometry) , retrospective cohort study , thyroid cancer , papillary thyroid cancer , follicular phase , thyroid carcinoma , oncology , cancer , pathology , gynecology , physics , optics
Background The incidence of thyroid cancer is increasing worldwide at an alarming rate. BRAF V600E mutation is described to be associated with a worse prognostic of thyroid carcinomas, as well as extrathyroidal invasion and increased mortality. Objective To our knowledge, there are no reported studies neither from Morocco nor from other Maghreb countries regarding the prevalence of BRAF V600E mutation in thyroid carcinomas. Here we aim to evaluate the frequency of BRAF V600E oncogene in Moroccan thyroid carcinomas. Methods In this Single-Institution retrospective study realized in the Anatomic Pathology and Histology Service in the Military Hospital of Instruction Mohammed V ‘HMIMV’ in Rabat, we report, using direct genomic sequencing, the assessment of BRAF V600E in 37 thyroid tumors. Results We detected BRAF V600E mutation exclusively in Papillary Thyroid Carcinomas ‘PTC’ with a prevalence of 28% (8 PTC out 29 PTC). Like international trends, Papillary Thyroid Carcinomas ‘PTC’ is more frequent than Follicular Thyroid Carcinomas ‘FTC’ and Anaplastic Thyroid Carcinomas ‘ATC’ (29 PTC, 7 FTC and 1 ATC). Conclusion Our finding gives to the international community the first estimated incidence of this oncogene in Morocco showing that this prevalence falls within the range of international trends (30% to 90%) reported in distinct worldwide geographic regions.