Association of Rs61764370 polymorphism within let-7 microRNA-binding site with lung cancer in Iranian population

Polymorphisms within miRNAs binding sites are associated with miRNAs function. The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population. Methods: This case-control study was conducted with 100 lung cancer patients and 100 healthy persons. The rs61764370 polymorphism was analyzed using PCR-RFLP technique and direct sequencing. Results: We found a significant relationship between rs61764370 (T / G) polymorphism and lung cancer risk, the GT gen- otype (OR: 6.25; 95% CI = 2.605-15.00; P= 0.000) and G allele (OR: 5.25; 95% CI = 2.259–12.208; P= 0.000) were signifi- cantly associated with an increased risk of lung cancer. Conclusion: According to our findings, there is a significant relationship between the KRAS rs61764370 polymorphism and lung cancer risk in Iranian population and this polymorphism may be used as a marker in detection of lung cancer in the future. Keywords: Polymorphism; KRAS; lung cancer; Let-7.