Frequency of IL-10+CD19+ B cells in patients with prostate cancer compared to patients with benign prostatic hyperplasia | Zendy

Roya Nazmabadi | Zendy; Fatemeh Taheri | Zendy; Mohammad-Alibeigi Faramarz | Zendy; Sabzevary-Ghahfarokhi Milad | Zendy; Sanaei Mohammad-Javad | Zendy; Najmeh Salehi-Vanani | Zendy; Yousef Mirzaei | Zendy; Nader Bagheri | Zendy

Open Access

Frequency of IL-10+CD19+ B cells in patients with prostate cancer compared to patients with benign prostatic hyperplasia

Author(s) -

Roya Nazmabadi,

Fatemeh Taheri,

Mohammad-Alibeigi Faramarz,

Sabzevary-Ghahfarokhi Milad,

Sanaei Mohammad-Javad,

Najmeh Salehi-Vanani,

Yousef Mirzaei,

Nader Bagheri

Publication year - 2020

Publication title -

african health sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 44

eISSN - 1729-0503

pISSN - 1680-6905

DOI - 10.4314/ahs.v20i3.31

Subject(s) - cd19 , medicine , regulatory b cells , prostate cancer , immune system , interleukin 10 , hyperplasia , prostate , immunohistochemistry , cancer , immunology

Background: The function of the immune system in prostate cancer (PC) might promote carcinogenesis. PC is a common cancer in men. Regulatory B cells (Bregs) are a new subtype of B cells that have suppressive roles in the immune system. Inter- leukin-10 (IL-10) is a dominant mediator of immune suppression released by Bregs. Objective: The purpose of this research was to examine the frequency of CD19+IL10+ B cells and IL-10 mRNA expression in patients with PC compared to patients with benign prostatic hyperplasia (BPH). Methods: Forty paraffin tissue samples from patients with PC and 32 paraffin tissue samples from patients with BPH were en- tered in this study. The immunohistochemistry staining was used to evaluate the pattern expression of CD19 and IL-10 markers. IL-10 mRNA expression in fresh tissue was determined by real time-polymerase chain reaction (RT-PCR). Results: The frequency of CD19+IL-10+ B cells and IL-10 mRNA expression in PC patients were significantly higher than patients with BPH. Also, there was no meaningful relationship between the frequency of IL-10+CD19+ B cells and gleason scores in patients with PC. Conclusions: Our findings suggested that frequency of IL-10+CD19+ B cells correlates with progressive stage of PC. Keywords: Prostate cancer; benign prostatic hyperplasia; IL-10+CD19+ B cells.

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