Open AccessWeight reduction improves immune system and inflammatory cytokines in obese asthmatic patients
Author(s) -
Fadwah M Al-Sharif,
Shehab M Abd El-Kader,
Ziyad Neamatallah,
Afnan M. Alkhateeb
Publication year - 2020
Publication title -
african health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 44
eISSN - 1729-0503
pISSN - 1680-6905
DOI - 10.4314/ahs.v20i2.44
Subject(s) - medicine , asthma , immune system , body mass index , obesity , inflammation , systemic inflammation , weight loss , immunology , cd8 , immune dysregulation , gastroenterology
Background: Activation of immunological and systemic inflammation markers are common in obesity and asthma.
Objective: The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.
Material and methods: Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 ± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).
Results: The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.
Conclusion: Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.
Keywords: Bronchial asthma; cytokines; obesity; immune system; weight reduction.