Open AccessFrequency and severity of ketoacidosis at diagnosis among childhood type 1 diabetes in Khartoum state, Sudan
Author(s) -
Ahmed M. Ahmed,
Omar F. Khabour,
Samia Mahdi Ahmed,
Ibrahim A Alebaid,
Amna Ibrahim
Publication year - 2020
Publication title -
african health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 44
eISSN - 1729-0503
pISSN - 1680-6905
DOI - 10.4314/ahs.v20i2.38
Subject(s) - medicine , diabetic ketoacidosis , type 1 diabetes , pediatrics , diabetes mellitus , mortality rate , complication , ketoacidosis , retrospective cohort study , endocrinology
Background: Diabetic ketoacidosis (DKA) is a potentially life threatening acute complication of Type I diabetes mellitus (T1DM). This study aimed to determine the frequency and clinical characteristics of pediatric DKA at diagnosis of new-onset T1DM in Khartoum during 2000- 2017 period.
Methods: The study was retrospective and involved review of medical files of children (<15 years) with T1DM in the city hos- pitals and diabetes centers.
Results: The overall frequency of DKA among T1DM children at onset of disease diagnosis was 17.6% (173/982). The epi- sodes of DKA increased from 26% in first 6- year period (2000-2005) to 46.3% in the last 6-year period (2011-2012; p<0.001). No significant difference in the frequency of DKA was observed according to gender (p=0.9) and age (p=0.24). Compared to other age groups, the severity of DKA (pH<7.1) was higher in pre-school children (p<0.01). Approximately, 5% of patients were complicated with cerebral edema with a mortality rate of 1.7%.
Conclusion: The DKA frequency at diagnosis of childhood T1DM in Khartoum was lower than previous reports. In addition, the severity of DKA was high among pre-school age children with a relatively high mortality rate when compared to the global rate.
Keywords: Ketoacidosis; mortality; onset; DKA; T1DM; Sudan; Khartoum.