Open AccessNovel nonsense mutation of BRCA2 gene in a Moroccan man with familial breast cancer
Author(s) -
Soukaina Guaoua,
Ilham Ratbi,
Jaber Lyahyai,
El Alaoui Sc,
Fatima Zahra Laarabi,
Abdelaziz Sefiani
Publication year - 2014
Publication title -
african health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.391
H-Index - 44
eISSN - 1729-0503
pISSN - 1680-6905
DOI - 10.4314/ahs.v14i2.25
Subject(s) - breast cancer , germline mutation , medicine , nonsense mutation , germline , brca2 protein , genetics , mutation , gene , nonsense , cancer , cancer research , biology , missense mutation
Breast cancer is the most common cancer in women worldwide. About 5 to 10% of cases are due to an inherited predisposition in two major genes, BRCA1 and BRCA2, transmitted as an autosomal dominant form. Male breast cancer is rare and is mainly due to BRCA2 than BRCA1 germline mutations.