Open AccessInvolvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma
Author(s) -
Takuma Hayashi,
Akiko Horiuchi,
Kenji Sakai,
Nobuyoshi Hiraoka,
Mari Kasai,
Tsuyoshi Ichimura,
Satoru Nagase,
Osamu Ishiko,
Tanri Shiozawa,
Yae Kanai,
Nobuo Yaegashi,
Hiroyuki Aburatani,
Susumu Tonegawa,
Ikuo Konishi
Publication year - 2011
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4297/najms.2011.3394
Subject(s) - flood myth , population , agriculture , production (economics) , geography , agroforestry , medicine , biology , environmental health , archaeology , economics , macroeconomics
Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma is extremely malignant, with high rates of recurrence and metastasis. The development of gynecologic tumors is often correlated with secretion of female hormone; however, the development of human uterine leiomyosarcoma is not substantially correlated with hormonal conditions, and the risk factors are unclearly understood. Importantly, a diagnostic-biomarker, which distinguishes malignant human uterine leiomyosarcoma from benign tumor leiomyoma is yet to be established.