Open AccessPlecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
Author(s) -
Kunwar Shailubhai,
Vaseem A. Palejwala,
Krishna Priya Arjunan,
Sayali Saykhedkar,
Bradley Nefsky,
John A. Foss,
Stephen Comiskey,
Gary S. Jacob,
Scott E. Plevy
Publication year - 2015
Publication title -
world journal of gastrointestinal pharmacology and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2150-5349
DOI - 10.4292/wjgpt.v6.i4.213
Subject(s) - colitis , pharmacology , inflammatory bowel disease , medicine , ulcerative colitis , sulfasalazine , cyclic guanosine monophosphate , nitric oxide , disease
To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.