Open AccessBowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine in rats
Author(s) -
Lidija Berkopic Cesar,
Slaven Gojković,
Ivan Krezić,
Dominik Malekinušić,
Helena Žižek,
Lovorka Batelja Vuletić,
Andreja Petrović,
Katarina Horvat Pavlov,
Domagoj Drmić,
Antonio Kokot,
Josipa Vlainić,
Sven Seiwerth,
Predrag Sikirić
Publication year - 2020
Publication title -
world journal of gastrointestinal pharmacology and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2150-5349
DOI - 10.4292/wjgpt.v11.i5.93
Subject(s) - medicine , adhesion , arginine , gastroenterology , bowel obstruction , surgery , biochemistry , chemistry , amino acid , organic chemistry
After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation. We hypothesized that unlike nitric oxide (NO)-agents, L-NAME and/or L-arginine, the application of the stable gastric pentadecapeptide BPC 157 with its most recent vascular effects ("vascular recruitment") means attenuated bowel adhesion formation and NO- and malondialdehyde (MDA)-tissue values.