Open AccessGenetic update on inflammatory factors in ulcerative colitis: Review of the current literature
Author(s) -
Silvia Patrícia,
Erzsébet Kövesdi,
Lili Magyari,
Zsolt Bánfai,
András Szabó,
Andras Javorhazy,
Béla Melegh
Publication year - 2014
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v5.i3.304
Subject(s) - ulcerative colitis , medicine , inflammatory bowel disease , inflammation , disease , immunology , immune system , crohn's disease , genome wide association study , bioinformatics , genetic predisposition , gene , single nucleotide polymorphism , genetics , genotype , biology
Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammation-related genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.