Open AccessReview to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma
Author(s) -
Yoshinori Sanada,
Yujo Kawashita,
Satomi Okada,
Takashi Azuma,
Shigetoshi Matsuo
Publication year - 2014
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v5.i3.188
Subject(s) - histogenesis , intrahepatic cholangiocarcinoma , medicine , pathology , surgical resection , radiology , immunohistochemistry
Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma (ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.