Open AccessPotential role of NADPH oxidase in pathogenesis of pancreatitis
Author(s) -
Wei-Li Cao,
Xiao-Hui Xiang,
Kai Chen,
Wei Xu,
Shihai Xia
Publication year - 2014
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v5.i3.169
Subject(s) - nicotinamide adenine dinucleotide phosphate , nadph oxidase , reactive oxygen species , pathogenesis , pancreatitis , microbiology and biotechnology , signal transduction , medicine , acute pancreatitis , oxidase test , biochemistry , cancer research , biology , immunology , enzyme
Studies have demonstrated that reactive oxygen species (ROS) are closely related to inflammatory disorders. Nicotinamide adenine dinucleotide phosphate oxidase (NOX), originally found in phagocytes, is the main source of ROS in nonphagocytic cells. Besides directly producing the detrimental highly reactive ROS to act on biomolecules (lipids, proteins, and nucleic acids), NOX can also activate multiple signal transduction pathways, which regulate cell growth, proliferation, differentiation and apoptosis by producing ROS. Recently, research on pancreatic NOX is no longer limited to inflammatory cells, but extends to the aspect of pancreatic acinar cells and pancreatic stellate cells, which are considered to be potentially associated with pancreatitis. In this review, we summarize the literature on NOX protein structure, activation, function and its role in the pathogenesis of pancreatitis.