Open AccessCommon polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian
Author(s) -
Kaushik Chatterjee,
Amit Kumar Dutta,
Ashish Goel,
Rekha Aaron,
B. Vijayalekshmi,
Ajith J. Thomas,
Anoop John,
Rajeeb Jaleel,
Deepu David,
Reuben Thomas Kurien,
S. R. Chowdhury,
Ebby George Simon,
Abraham Joseph,
Prasanna Samuel Premkumar,
Anna Pulimood
Publication year - 2022
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v13.i4.114
Subject(s) - genotype , medicine , single nucleotide polymorphism , crohn's disease , allele , restriction fragment length polymorphism , disease , immunology , snp , gene , case control study , population , gastroenterology , genetics , biology , environmental health
Multiple genetic risk factors for Crohn's disease (CD) have been identified. However, these observations are not consistent across different populations. The protein tyrosine phosphate non-receptor type 2 ( PTPN2 ) gene plays a role in various aspects of host defense including epithelial barrier function, autophagy, and innate and adaptive immune response. Two common polymorphisms in the PTPN2 gene (rs2542151 and rs7234029) have been associated with risk of CD in Western countries.