Open AccessAtherosclerotic cardiovascular disease in inflammatory bowel disease: The role of chronic inflammation
Author(s) -
Simcha Weissman,
Preetika Sinh,
Tej I Mehta,
Rishi Thaker,
Abraham Derman,
Caleb Heiberger,
Nabeel Qureshi,
Viralkumar Amrutiya,
Adam Atoot,
Maneesh Dave,
James H. Tabibian
Publication year - 2020
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v11.i5.104
Subject(s) - medicine , inflammatory bowel disease , rheumatoid arthritis , inflammation , atherosclerotic cardiovascular disease , disease , systemic inflammation , intensive care medicine , immunology
Inflammatory bowel disease (IBD) causes systemic vascular inflammation. The increased risk of venous as well as arterial thromboembolic phenomena in IBD is well established. More recently, a relationship between IBD and atherosclerotic cardiovascular disease (ASCVD) has been postulated. Systemic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus, have well characterized cardiac pathologies and treatments that focus on prevention of disease associated ASCVD. The impact of chronic inflammation on ASCVD in IBD remains poorly characterized. This manuscript aims to review and summarize the current literature pertaining to IBD and ASCVD with respect to its pathophysiology and impact of medications in order to encourage further research that can improve understanding and help develop clinical recommendations for prevention and management of ASCVD in patients with IBD.